1. Dietary supplements in Integrative Medicine
2. Anti-aging and chemopreventative functions of natural products
3. Dietary supplements and functional foods in cancer prevention and anti-aging
4. Molecular basis of traditional medicine in disease prevention and anti-aging
5. Brain oxidative stress and diseases
6. Lifestyle disease
7. The role of diet in epigenetic modification of gene regulation
8. Anti-oxidant herbs and cellular stress response

Nov 28
16:00～19:00	Registration Desk
19:00～21:00	Welcome Reception
Nov 29 : Chemopreventive function of diet and natural products
08:45～09:00	Opening Remark and 4th INS Perspective	Tetsuya Konishi, Ph.D. (NUPALS)
09:05～09:45	Plenary Lecture	“Multitargeted Therapy by Natural Products; Add Spice to Your Life” Bharat B. Aggarwal, Ph.D. (MD Anderson Cancer Center, Univ Tx, Houston, USA)
09:45～10:05	Symposium Sessions	“Anticarcinogenic functions of selenium: Induction of apoptosis and inhibition of tumor metastatis” An-Sik Chung, Ph.D. (Korea Advanced Institute of Science and Technology, Korea)
10:05～10:25		"Marine compounds as promising anti-cancer agents" Marc Diederich, Ph.D. (Laboratoire de Biologie Moleculaire et Cellulaire du Cancer, Luzembourg)
10:25～10:45		“Study on the regulation of the telomerase activation in hepatocarcinogenesis treated by HQS” Xuejiang Wang M.D. (School of Basic Medical Sciences of Capital Medical University, Beijin, P.R.China)
10:45～11:00	Break
11:00～11:55	Keynote Lecture	“Chemopreventive functions of diet and natural products” John A. Milner, Ph.D. (National Cancer Institute, Bethesda, USA)
11:55～12:15	Group Photo	at Side walk Terrace
12:15～13:10	Sponsored Seminer	Basic and clinical studies on chemopreventive and anti-oxidant activity of natural products Masatoshi Yamazaki, Ph.D. (Dept of Pharmacy, Teikyou University, Tokyo, Japan)
13:10～14:30	Poster Session	Chairperson: Tomohiro Nabekura Ph.D. (NUPALS) Session chair: Bharat Aggarwal Ph.D, Toshiyuki Sakamaki Ph.D. Poster session guideline
14:30～15:00	Plenary Lecture	“Gastronomic epigenetics; Broccoli with garlic sauce for histone deacetylase inhibition?” Roderick H. Dashwood, Ph.D. (Linus Pauling Institute, Oregon State University, USA)
15:00～15:20	Symposium Sessions	“The modulation of DNA damage checkpoint by natural products in cancer prevention” Hiroshi Nishida, Ph.D. (Dept of Functional Foods Sciences, NUPALS, Niigata, Japan)
15:20～15:40		"Induction of dendritic cell maturation and tumor cell apoptosis by PPC derived from a plant extract" Akiko Tanaka, Ph.D. (Tampa Bay Research Institute, Florida, USA)
15:40～16:00		Vipen Batra, Ph.D. (Bhabha Atomic Research Center, Mumbai, India)
16:00～16:20		“Analog of Resveratrol may be a better anticancer agent during NSAID-induced gastric Ulcer” Sandip K Bandyopadhyay, M.Sc, Ph.D. (Department of Biochemistry, Institute of Post Graduate Medical Education and Research, Kolkata, India)
16:20～16:50		“The mechanism of anti-tumor and anti-aging effect of medicated food in Chinese Medicine” Pengtao Li, M.D., Ph.D. (Preclinical Medicine School, Beijing University of Chinese Medicine, Beijing, P.R.China)
18:30～21:00	Banquet	Hotel Nikko, Top Floor
Nov 30 : "Anti-aging Strategy as Disesase Prevention"
08:45～09:05	Opening Remark	Chairperson: Young-Joon Surh Ph.D., Noriko Noguchi Ph.D.
09:00～09:40	Plenary Lecture	“Antioxidants and Prooxidants in diet” Barry Halliwell, Ph.D, D.Sc. (National University of Singapore Graduate Schoolfor Integrative Sciences and Engineering, Singapore)
09:40～10:00	Symposium Sessions	"High antioxidant activity and phytochemicals of herbal plants used in Thai cooking and their potential role in cancer prevention" Maitree Suttajit, Ph.D. (School of Science and Technology, Naresuan University at Phayao, Thailand)
10:00～10:20		“Studying the dietary modulation of inflammation by combining in vivo and in vitro models” Fabio Virgili, Ph.D. (National Institute on Food and Nutrition Research, Rome, Italy)
10:20～10:35	Break
10:35～10:55	Symposium Sessions	“Gene regulation by antioxidants and oxidants against atherosclerosis” Noriko Noguchi, Ph.D. (Doshisha University, Japan)
10:55～11:15		“Cancer Prevention by Rice Bran Tocotrierols” Teruo Miyazawa Ph.D. ( Tohoku University, Sendai, Japan)
11:15～11:35		“Long-term schisandrin B treatment mitigates the age-related impairment in mitochondrial antioxidants status and functional ability in various tissues, and improves the survival of aging male C57BL/6J mice” Robert Kam-Ming KO, Ph.D., (Department of Biochemistry, Hong Kong University of Science and Technology, Hong kong, P.R.China)
11:35～12:05	Plenary Lecture	"French Paradox Revisited Scientifically: Chemopreventive and Antiaging Properties of Resveratrol in Red Wine" Young-Joon Surh, Ph.D. (National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, Korea)
12:05～13:00	Sponsored Seminar	Chairperson: Nishiumi Ph.D. (Niigata Univ) Functional Modification of Foods by Hi-pressure treatment (tentative) Tomoyuki Fujii, Ph.D. (Gunnma Institute of Technology, Maebashi, Japan)
13:00-13:15	Coffee Break
13:15～13:45	Plenary Lecture	“The study on herbal resources from China Chanbai Mountains used for healthystuff” Deng Ming Lu (Changchun University of Chinese Medicine, Changchun, P.R.China)
13:45～14:05	Symposium Sessions	“Preventive effects of kampo medicines on infectious diseases and neural disease” Haruki Yamada, Ph.D. (Kitazato University)
14:05～14:35	Plenary Lecture	“Expression of the longevity genes and proteins by wines and their cardioprotective components, resveratrol, tyrosol and hydoroxytyrosol” Dipak K. Das, Ph.D., Sc.D., M.D.(hon), (Cardiovascular Research Center, University of Connecticut School of Medicine, Connecticut, USA)
14:35～14:55	Symposium Sessions	“Anti-aging medicine:resent progress in the clinical field” Akira Kubo, MD. (Takanawa Medical Clinic, Prof Tokai University Medical School, Tokyo, Japan)
14:55～15:10	Coffee Break
15:10～15:30	Symposium Sessions	“Personalized food: how personal is it ?” Dilip Ghosh, Ph.D., FACN (Regulatory and Scientific Affairs Consultant Wollongong, New South Wales, Australia)
15:30～15:50		Superfruit:Intelligent Synergies for functional Foods of the Future" Arjan Scheepens, Ph.D. (Neuroscience Foods for Health, HortResearch, Auckland, New Zealand)
15:50～16:20	Plenary Lecture	“Molecular mechanism of obesity regulation by a novel, natural extract of (-)-hydroxy citric acid” Debasis Bagchi, Ph.D (InterHealth Research Center, Benicia, California; University of Houston College of Pharmacy, Houston, Texas, USA)
16:20～16:30	Closing Remark	Tadao Kurata, Ph.D. (NBRP)

[Deadline of Abstract Submission - August 10, 2008]
[Early Registration - September 30, 2008]

Registration Fee

	Pay Before September 30, 2008	Pay After October 1, 2008	Pay On-site
Commercial Firm (Accompanying persons)	JPY40,000 (JPY5,000)	JPY50,000 (JPY7,000)	JPY60,000 (JPY10,000)
Student participant	JPY2,000	JPY4,000	JPY5,000
Regular participant	JPY20,000	JPY25,000	JPY30,000

On-line Registration is by November 10, 2008

The Deadline of Submission is by September 30, 2008
Please submit your abstract in English through the website using the Entry form attached.

Food & Flower World Forum Niigata 2008 Organizing Committee

Oxygen Club of California (OCC)
Society of Translational Cancer Research
Linus Pauling Institute, Oregon State University
Niigata Food Farm Association (Niigata Shokuhin Sangyo Kyoukai)
Niigata University of Pharmacy and Applied Life Sciences (NUPALS)
Niigata Bio-Research Park,Inc.

4th International Niigata Symposium on Diet and Health Organizing Committee
Society of Anti-aging Food Functions Society of Niigata

International Advisory Committee

• Akiko Tanaka (Tampa Bay Research Institute, Florida, USA)
• An-Sik Chung (Korea Advanced Institute of Science and Technology, Taejon, Korea)
• Bharat B. Aggarwal (MD Anderson Cancer Center, Texas, USA)
• Ceasar G.Fraga (University of California, USA)
• Deng Ming Lu (Changchun University of Chinese Medicine, P.R.China)
• nrique Cadenas (University of Southern California, USA)
• Fabio Virgili (National Research Institute on Food and Nutrition, Rome, Italy)
• JianKan Liu (University of Southern California, USA)
• Lester Packer (University of Southern California, USA)
• Madhusaudan G.Soni (Vero Beach Hematology Oncology, Florida, USA)
• Maitree Suttajit (School of Science and Technology Phayao Campus, Naresuan University, Thailand)
• Nobuo Ikekawa (NBRC, Niigata, Japan)
• Roderick H. Dashwood (Linus Pauling Institute, Oregon State University, USA)
• Robert K.M.Ko (HKUST, Hong Kong,P.R.China)
• Young-Joon Surh (Seoul National University, Korea)
• Wang Xuejiang (BCMU, Beijing, P.R.China)

Local Organizing Committee

Akihiko Saito (Niigata University Graduate School of Medical and Dental Sciences) Hideyuki Sone (Niigata Women's College) Hiroshi Urakami (NUPALS) Kenichi Watanabe (NUPALS) Masao Hirayama (NUPALS) Noriko Miyake (NUPALS) Shinji Sato (NUPALS) Tadayuki Nishiumi (Niigata University)v Tomoyuki Fujii (Maebashi Institute of Technology) Toshio Jo (Niigata University)

Chigusa Tateyama (Niigata Women's College) Hiroshi Nishida (NUPALS) Katsumi Ajisaka (NUPALS) Koji Sato (NUPALS) Motoni Kadowaki (Niigata University) Shinichi Ichikawa (NUPALS) Tadao Kurata (Niigata Bio-Research Park,Inc.) Tomohiro Nabekura (NUPALS) Toru Shigematu (NUPALS) Toshiyuki Sakamaki (NUPALS) Tetsuya Konishi (NUPALS) (Chairman)

4th International Niigata Symposium on Diet & Health Organizing Committee:

c/o Niigata Bio-Research Center
Higashijima 316-2, Akiha-Ku, Niigata-City, Niigata 956-0841, Japan
NUPALS Office: Phone/Fax: +81-(0)250-25-5126
Secretary Office: Phone/Fax: +81-(0)250-25-1123

Chairman, 4th INS Organizing Committee:

Dr. Tetsuya Konishi (NUPALS)

General Office:

Office for executing Food & Flower World Forum
c/o Food and Flower Promotion Division, Niigata City
Hakusanura 1-425-9, Chuuou-Ku, Niigata-City, Niigata 951-8131, Japan
Phone:+81-(0)25-226-3567 Fax:+81-(0)25-230-0423

Niigata Convention Center
Niigata City is a harbor city located in northwestern Tokyo. It is the largest city on the western coast of the Honshu island of Japan. Travel time is about 2 hours from Tokyo by Shinkansen train or 1 hour by air from Osaka.

Niigata City is located on the western coast of the main island of Japan and is well known worldwide for producing the best Kome (rice) in Japan. Besides Kome, Niigata City also produces many agricultural products including fruits and vegetables, flowers and sea products. The advantages of such agricultural and natural resources have made Niigata City a major hub for the food manufacturing industry. Many fine food products, including health-oriented and anti-aging functional foods, are available. The city has held the World Forum on Flowers and Foods every year since 2005, and a number of Symposium, congresses and exhibitions have been scheduled for the general public. The International Niigata Congress and Symposium on Diet and Health is the major event of the Forum. Each year, several expert speakers are invited from around the world to discuss specific topics, such as "The Safety and Supply of Foods" (2005), "Food Functions" (2006), and "Shoku-iku (food culture education)" this year. The Symposium has also addressed related topics such as "Food safety: risk and benefit," "Health beneficial functions of food," and "Sensing, taste, flavor and texture."in 2007, there was a special emphasis on "Umami."

For the 2008 Symposium, the organizers have decided to address the role of functional foods and supplements in Integrative Medicine and how they are related to the development of anti-aging and anti-cancer strategies. The Organizing Committee cordially invites you to join with us to discuss these interesting topics in Niigata on November 29-30, 2008.